Neuroanatomía funcional de enfermedades raras
LÍNEA DE INVESTIGACIÓN
Investigación de las bases neuroanatómicas y neuroendocrinológicas de las alteraciones en el comportamiento social y olfativo modelos murinos de síndrome de Rett y otras enfermedades raras del neurodesarrollo.
UBICACIÓN
Departament de Biologia Cel·lular i Biologia Funcional, Facultat de Ciències Biològiques, Universitat de València
Miembros del equipo
INVESTIGADORA PRINCIPAL
- Carmen Agustín Pavón
MIEMBROS
- Rafael Esteve Pérez
- Daniela Jiménez Díaz
- Vicente Herranz Pérez
- Ana Martín Sánchez
Publicaciones recientes
Altered Microglial Plasticity in the Periaqueductal Grey of Pre-Symptomatic Mecp2-Heterozygous Mice Following Early-Life Stress
Abellán-Álvaro M, Primo-Hernando L, Martínez-Rodríguez E, Lanuza E, Santos M, Agustín-Pavón C, Torres-Pérez JV. Altered Microglial Plasticity in the Periaqueductal Grey of Pre-Symptomatic Mecp2-Heterozygous Mice Following Early-Life Stress. Neuromolecular Med. 2025 Jun 17;27(1):46.
The density of doublecortin cells in the piriform cortex is affected by transition to adulthood but not first pregnancy in mice
Esteve-Pérez R, Abellán-Álvaro M, Navarro-Moreno C, Prina M, Barneo-Muñoz M, Lanuza E, Sánchez-Catalán MJ, Martínez-García F, Torres-Pérez JV, Agustín-Pavón C. The density of doublecortin cells in the piriform cortex is affected by transition to adulthood but not first pregnancy in mice. Brain Struct Funct. 2025 Jun 10;230(6):94.
Disorders of puberty and neurodevelopment: A shared etiology?
Read JE, Vasile-Tudorache A, Newsome A, Lorente MJ, Agustín-Pavón C, Howard SR. Disorders of puberty and neurodevelopment: A shared etiology? Ann N Y Acad Sci. 2024 Nov;1541(1):83-99. doi: 10.1111/nyas.15246. Epub 2024 Oct 21.
Doublecortin-immunoreactive neurons in the piriform cortex are sensitive to the long lasting effects of early life stress
Abellán-Álvaro M, Teruel-Sanchis A, Madeira MF, Lanuza E, Santos M, Agustín-Pavón C. Doublecortin-immunoreactive neurons in the piriform cortex are sensitive to the long lasting effects of early life stress. Front Neurosci. 2024 Sep 16;18:1446912. doi: 10.3389/fnins.2024.1446912.
Publicaciones más relevantes
Lack of MeCP2 leads to region-specific increase of doublecortin in the olfactory system
Martínez-Rodríguez E, Martín-Sánchez A, Coviello S, Foiani C, Kul E, Stork O, Martínez-García F, Nacher J, Lanuza E, Santos M, Agustín-Pavón C. Lack of MeCP2 leads to region-specific increase of doublecortin in the olfactory system. Brain Struct Funct. 2019 May;224(4):1647-1658. doi: 10.1007/s00429-019-01860-6. Epub 2019 Mar 28.
Male-specific features are reduced in Mecp2-null mice: analyses of vasopressinergic innervation, pheromone production and social behaviour
Martínez-Rodríguez E, Martín-Sánchez A, Kul E, Bose A, Martínez-Martínez FJ, Stork O, Martínez-García F, Lanuza E, Santos M, Agustín-Pavón C. Male-specific features are reduced in Mecp2-null mice: analyses of vasopressinergic innervation, pheromone production and social behaviour. Brain Struct Funct. 2020 Sep;225(7):2219-2238. doi: 10.1007/s00429-020-02122-6. Epub 2020 Aug 4.
MeCP2 haplodeficiency and early-life stress interaction on anxiety-like behavior in adolescent female mice
Abellán-Álvaro M, Stork O, Agustín-Pavón C, Santos M. MeCP2 haplodeficiency and early-life stress interaction on anxiety-like behavior in adolescent female mice. J Neurodev Disord. 2021 Dec 11;13(1):59. doi: 10.1186/s11689-021-09409-7.
Early life stress exacerbates behavioural and neuronal alterations in adolescent male mice lacking methyl-CpG binding protein 2 (Mecp2)
Torres-Pérez JV, Martínez-Rodríguez E, Forte A, Blanco-Gómez C, Stork O, Lanuza E, Santos M, Agustín-Pavón C. Early life stress exacerbates behavioural and neuronal alterations in adolescent male mice lacking methyl-CpG binding protein 2 (Mecp2). Front Behav Neurosci. 2022 Aug 23;16:974692. doi: 10.3389/fnbeh.2022.974692.