Neuroplasticidad y neurodegeneracion
LÍNEA DE INVESTIGACIÓN
Aproximaciones -ómicas: proteómica y bioinformática. Cambios neuroanatomicos en el cerebro humano en las enfermedades de Alzheimer y Parkinson. Cambios neuronales y gliales en el cerebro humano en las enfermedades de Alzheimer, Parkinson y Huntington. Proteinopatías y co-patologías asociadas a las enfermedades de Alzheimer, Parkinson y Huntington
UBICACIÓN
Departamento de Anatomía y Embriología Humana, Universidad de Castilla la Mancha
Miembros del equipo
INVESTIGADOR PRINCIPAL
- Martínez Marcos, Alino
MIEMBROS
- Alicia María Flores Cuadrado
- Isabel María Úbeda Bañón
- Julia Vaamonde Gamo
- Juan Pablo Cabello de la Rosa
- Verónica Astillero López
- Ana Paula Flores Thomas
- Andrea Alonso Gómez
Publicaciones recientes
The chaperones HSP90AA1, HSP90AB1 and BAG3 are specifically distributed among human hippocampal subfields during different Alzheimer's disease stages
Soriano-Herrador C, Ubeda-Banon I, Villanueva-Anguita P, Saiz-Sanchez D, Astillero-Lopez V, Martinez-Marcos A, Flores-Cuadrado A. The chaperones HSP90AA1, HSP90AB1 and BAG3 are specifically distributed among human hippocampal subfields during different Alzheimer’s disease stages. Neurobiol Dis. 2025 Aug;212:106971. doi: 10.1016/j.nbd.2025.106971. Epub 2025 May 26. PMID: 40436281.
Anatomical dissection influences emotions of podiatry students
Mohedano-Moriano A, Romo-Barrientos C, Flores-Cuadrado A, Ubeda-Bañon I, Gonzalez-Gonzalez J, Gil Ruiz MT, Saiz-Sanchez D, Astillero-Lopez V, Marcos-Tejedor F, Martinez-Marcos A, Viñuela A, Criado-Alvarez JJ. Anatomical dissection influences emotions of podiatry students. J Foot Ankle Res. 2025 Mar;18(1):e70027. doi: 10.1002/jfa2.70027. PMID: 39804225; PMCID: PMC11727409.
Differential accumulation of human β-amyloid and tau from enriched extracts in neuronal and endothelial cells
Rabanal-Ruiz Y, Pedrero-Prieto CM, Sanchez-Rodriguez L, Flores-Cuadrado A, Saiz-Sanchez D, Frontinan-Rubio J, Ubeda-Banon I, Duran Prado M, Martinez-Marcos A, Peinado JR. Differential accumulation of human β-amyloid and tau from enriched extracts in neuronal and endothelial cells. Biochim Biophys Acta Mol Basis Dis. 2024 Jun;1870(5):167204. doi: 10.1016/j.bbadis.2024.167204. Epub 2024 Apr 27. PMID: 38679217.
Proteomic analysis identifies HSP90AA1, PTK2B, and ANXA2 in the human entorhinal cortex in Alzheimer's disease: Potential role in synaptic homeostasis and Aβ pathology through microglial and astroglial cells
Astillero-Lopez V, Villar-Conde S, Gonzalez-Rodriguez M, Flores-Cuadrado A, Ubeda-Banon I, Saiz-Sanchez D, Martinez-Marcos A. Proteomic analysis identifies HSP90AA1, PTK2B, and ANXA2 in the human entorhinal cortex in Alzheimer’s disease: Potential role in synaptic homeostasis and Aβ pathology through microglial and astroglial cells. Brain Pathol. 2024 Jul;34(4):e13235. doi: 10.1111/bpa.13235. Epub 2024 Jan 22. PMID: 38247340; PMCID: PMC11189773.
Synaptic Involvement of the Human Amygdala in Parkinson's Disease
Villar-Conde S, Astillero-Lopez V, Gonzalez-Rodriguez M, Saiz-Sanchez D, Martinez-Marcos A, Ubeda-Banon I, Flores-Cuadrado A. Synaptic Involvement of the Human Amygdala in Parkinson’s Disease. Mol Cell Proteomics. 2023 Dec;22(12):100673. doi: 10.1016/j.mcpro.2023.100673. Epub 2023 Oct 29. PMID: 37947401; PMCID: PMC10700869.
Human amygdala involvement in Alzheimer's disease revealed by stereological and dia-PASEF analysis
Gonzalez-Rodriguez M, Villar-Conde S, Astillero-Lopez V, Villanueva-Anguita P, Ubeda-Banon I, Flores-Cuadrado A, Martinez-Marcos A, Saiz-Sanchez D. Human amygdala involvement in Alzheimer’s disease revealed by stereological and dia-PASEF analysis. Brain Pathol. 2023 Sep;33(5):e13180. doi: 10.1111/bpa.13180. Epub 2023 Jun 18. PMID: 37331354; PMCID: PMC10467039.