Células Madre y Neurología Traslacional

LÍNEA DE INVESTIGACIÓN

 Desarrollo de estrategias pioneras para proteger y reparar el sistema nervioso central en contextos de daño y enfermedad. Uso de células madre, modelos preclínicos y organoides cerebrales para terapias personalizadas. Prevención de secuelas neurológicas derivadas del cáncer cerebral pediátrico y sus tratamientos, explorando la vía intranasal como alternativa innovadora para administrar terapias celulares.

UBICACIÓN

Andalusian Molecular Biology and Regenerative Medicine Centre (CABIMER)

CONTACTO

vivian.capilla@cabimer.es

Miembros del equipo

INVESTIGADORA PRINCIPAL

  • Capilla González, Vivian

MIEMBROS

  • Jesús M Sierra Párraga
  • Laura Pérez Alos
  • Concepción Panadero Morón
  • Norma Adán Castro

Publicaciones recientes

Glioblastoma progression is hindered by melatonin-primed mesenchymal stromal cells through dynamic intracellular and extracellular reorganizations

Glioblastoma progression is hindered by melatonin-primed mesenchymal stromal cells through dynamic intracellular and extracellular reorganizations. Olmedo-Moreno L, Panadero-Morón C, Sierra-Párraga JM, Bueno-Fernández R, Norton ES, Aguilera Y, Mellado-Damas N, García-Tárraga P, Morales-Gallel R, Antequera-Martínez M, Durán RV, Ferrer-Lozano J, Escames G, García-Verdugo JM, Martin-Montalvo A, Guerrero-Cázares H, Capilla-González V. Theranostics. 2025 Feb 10;15(7):3076-3097. doi: 10.7150/thno.104143.

Palladium(II) and platinum(II) thiophene-based thiosemicarbazones: Synthesis, properties, and anticancer studies

Palladium(II) and platinum(II) thiophene-based thiosemicarbazones: Synthesis, properties, and anticancer studies. Oliveira GP, Lima MA, Pereira GBS, Costa AR, Batista AA, Forim MR, Cominetti MR, Zanetti RD, Farias RL, Netto AVG, Araujo-Neto JH, Ellena JA, Olmedo-Moreno L, Capilla-Gonzalez V, Rocha FV. Journal of Molecular Structure. 2025. 1322-Part 1. 140306, ISSN 0022-2860. doi.org/10.1016/j.molstruc.2024.140306.

Hydroxycitrate delays early mortality in mice and promotes muscle regeneration while inducing a rich hepatic energetic status

Hydroxycitrate delays early mortality in mice and promotes muscle regeneration while inducing a rich hepatic energetic status. Espadas I, Cáliz-Molina MÁ, López-Fernández-Sobrino R, Panadero-Morón C, Sola-García A, Soriano-Navarro M, Martínez-Force E, Venegas-Calerón M, Salas JJ, Martín F, Gauthier BR, Alfaro-Cervelló C, Martí-Aguado D, Capilla-González V, Martín-Montalvo A. Aging Cell. 2024 Sep;23(9):e14205. doi: 10.1111/acel.14205.

BCAS1 defines a heterogeneous cell population in diffuse gliomas

BCAS1 defines a heterogeneous cell population in diffuse gliomas. Morales-Gallel R, Ulloa-Navas MJ, García-Tárraga P, Prat-Acín R, Reynés G, Pérez-Borredá P, Rubio L, Capilla-González V, Ferrer-Lozano J, García-Verdugo JM. Oncotarget. 2024 Jan 24;15:49-64. doi: 10.18632/oncotarget.28553.

MAPK/MAK/MRK overlapping kinase (MOK) controls microglial inflammatory/type-I IFN responses via Brd4 and is involved in ALS

MAPK/MAK/MRK overlapping kinase (MOK) controls microglial inflammatory/type-I IFN responses via Brd4 and is involved in ALS. Pérez-Cabello JA, Silvera-Carrasco L, Franco JM, Capilla-González V, Armaos A, Gómez-Lima M, García-García R, Yap XW, Leal-Lasarte M, Lall D, Baloh RH, Martínez S, Miyata Y, Tartaglia GG, Sawarkar R, García-Domínguez M, Pozo D, Roodveldt C. Proc Natl Acad Sci. 2023 Jul 11;120(28):e2302143120. doi: 10.1073/pnas.2302143120.

Metabolic reprogramming by Acly inhibition using SB-204990 alters glucoregulation and modulates molecular mechanisms associated with aging

Metabolic reprogramming by Acly inhibition using SB-204990 alters glucoregulation and modulates molecular mechanisms associated with aging. Sola-García A, Cáliz-Molina MÁ, Espadas I, Petr M, Panadero-Morón C, González-Morán D, Martín-Vázquez ME, Narbona-Pérez ÁJ, López-Noriega L, Martínez-Corrales G, López-Fernández-Sobrino R, Castillo-Peña A, Carmona-Marin LM, Martínez-Force E, Yanes O, Vinaixa M, López-López D, Reyes JC, Dopazo J, Martín F, Gauthier BR, Scheibye-Knudsen M, Capilla-González V, Martín-Montalvo A. Commun Biol. 2023 Mar 8;6(1):250. doi: 10.1038/s42003-023-04625-4.

Generation of mesenchymal stromal cells from urine-derived iPSCs of pediatric brain tumor patients

Generation of mesenchymal stromal cells from urine-derived iPSCs of pediatric brain tumor patients. Baliña-Sánchez C, Aguilera Y, Adán N, Sierra-Párraga JM, Olmedo-Moreno L, Panadero-Morón C, Cabello-Laureano R, Márquez-Vega C, Martín-Montalvo A, Capilla-González V. Front Immunol. 2023 Jan 26;14:1022676. doi: 10.3389/fimmu.2023.1022676.

Publicaciones más relevantes

Therapeutic Potential of Mesenchymal Stem Cells for Cancer Therapy

Therapeutic Potential of Mesenchymal Stem Cells for Cancer Therapy. Hmadcha A, Martin-Montalvo A, Gauthier BR, Soria B, Capilla-Gonzalez V. Front Bioeng. Biotechnol. 2020 Feb 5;8:43. doi: 10.3389/fbioe.2020.00043.

Human Mesenchymal Stem Cells Prevent Neurological Complications of Radiotherapy

Human Mesenchymal Stem Cells Prevent Neurological Complications of Radiotherapy. Soria B, Martin-Montalvo A, Aguilera Y, Mellado-Damas N, López-Beas J, Herrera-Herrera I, López E, Barcia JA, Alvarez-Dolado M, Hmadcha A, Capilla-González V. Front Cell Neurosci. 2019 May 16;13:204. doi: 10.3389/fncel.2019.00204.

PDGF Restores the Defective Phenotype of Adipose-Derived Mesenchymal Stromal Cells from Diabetic Patients

PDGF Restores the Defective Phenotype of Adipose-Derived Mesenchymal Stromal Cells from Diabetic Patients. Capilla-González V, López-Beas J, Escacena N, Aguilera. Y, de la Cuesta A, Ruiz-Salmerón R, Martín F, Hmadcha A, Soria B. Mol Ther. 2018. Nov 7;26(11):2696-2709. doi: 10.1016/j.ymthe.2018.08.011.

 
A leak pathway for luminal protons in endosomes drives oncogenic signalling in glioblastoma

A leak pathway for luminal protons in endosomes drives oncogenic signalling in glioblastoma. Kondapalli KC, Llongueras JP, Capilla-González V, Prasad H, Hack A, Smith C, Guerrero-Cázares H, Quiñones-Hinojosa A, Rao R. Nat Commun. 2015 Feb 9;6:6289. doi: 10.1038/ncomms7289.

Age-related changes in astrocytic and ependymal cells of the subventricular zone

Age-related changes in astrocytic and ependymal cells of the subventricular zone. Capilla-Gonzalez V, Cebrian-Silla A, Guerrero-Cazares H, Garcia-Verdugo JM, Quiñones-Hinojosa A. Glia. 2014 May;62(5):790-803. doi: 10.1002/glia.22642.

The subventricular zone is able to respond to a demyelinating lesion after localized radiation

The subventricular zone is able to respond to a demyelinating lesion after localized radiation. Capilla-Gonzalez V, Guerrero-Cazares H, Bonsu JM, Gonzalez-Perez O, Achanta P, Wong J, Garcia-Verdugo JM, Quiñones-Hinojosa A. Stem Cells. 2014. Jan;32(1):59-69. doi: 10.1002/stem.1519.