Grupo de Neurobiología del Desarrollo-GNDe
LÍNEA DE INVESTIGACIÓN
Neurogénesis, oligodendrogliogénesis y mielinización durante el desarrollo del SNC y en el adulto normal. Desmielinización del SNC. Enfermedades desmielinizantes (esclerosis múltiple, leucodistrofias): fisiopatología y aproximaciones neuroreparativas. Síndrome de Kallmann. Historia de la Neurociencia
UBICACIÓN
Instituto Cajal-CSIC/Centro de Neurociencias Cajal, Madrid
Miembros del equipo
INVESTIGADOR PRINCIPAL
- de Castro Soubriet, Fernando
MIEMBROS
- Miguel Marchena
- Paula Gómez Martín
- Alba Macías
- Ángela Garrido
- Tania Martínez Sánchez
- Carolina Martín Falcón
- Maximiliano Torres Pérez
Publicaciones recientes
Extracellular matrix protein anosmin-1 overexpression alters dopaminergic phenotype in the CNS and the PNS with no pathogenic consequences in a MPTP model of Parkinson’s disease
Villadiego J, García-Swinburn R, Garcáa-González D, Lebrón-Galán R, Murcia-Belmonte V, García-Roldán E, Suárez-Luna N, Nombela C, Marchena M, de Castro# F, Toledo-Aral# JJ (2023) Extracellular matrix protein anosmin-1 overexpression alters dopaminergic phenotype in the CNS and the PNS with no pathogenic consequences in a MPTP model of Parkinson’s disease. Brain Struct. Funct. 228(3-4):907-920 (doi: https://doi.org/10.1007/s00429-023-02631-0 ).
Efficacy of a benzothiazole-based LRRK2 inhibitor in oligodendrocyte precursor cells and in a murine model of multiple sclerosis
Benítez-Fernández R, Josa-Prado F, Sánchez E, Laó Y, García-Rubia A, Cumella J, Martínez A, Palomo V & de Castro F (2024) Efficacy of a benzothiazole-based LRRK2 inhibitor in oligodendrocyte precursor cells and in a murine model of multiple sclerosis. CNS Neurosci. Ther. 30, e14552 (http://doi.org/10.1111/cns.14552 ).
Supporting central nervous system neuroprotection and remyelination by specific TLR4 antagonism
Fernández-Gómez B., Marchena MA, Piñeiro D, Laó Y, Valencia G, Nocera S, Benítez-Fernández R, Gómez-Martín P, Castaño-León AM, Lagares A, Hernández-Jiménez M, & de Castro F. (2024) Supporting central nervous system neuroprotection and remyelination by specific TLR4 antagonism. Br. J. Pharmacol. 181, 3263–3281 (doi: https://doi.org/10.1111/bph.16399 ; preprint publicado en bioRXiv doi: https://doi.org/10.1101/2023.01.22.524916 ).
Activation of Shh/Smo is sufficient to maintain oligodendrocyte precursor cells in an undifferentiated state and is not necessary for myelin formation and (re)myelination
Nocera S, Marchena# MA, Fernández-Gómez B, Gómez-Martín P, Sánchez-Jiménez E, Macías-Castellano A, Laó Y, Cordano C, Gómez-Torres Ó, Luján R, & de Castro# F. (2024) Activation of Shh/Smo is sufficient to maintain oligodendrocyte precursor cells in an undifferentiated state and is not necessary for myelin formation and (re)myelination. Glia 72, 1469–1483 (https://doi.org/10.1002/glia.24540 ; preprint publicado en bioRXiv doi: https://doi.org/10.1101/2023.06.23.546285 ).
Herpes Simplex Virus type 1 inhibits autophagy in glial cells but requires ATG5 for the success of viral replication
Ripa I, Andreu S, Fernández-Gómez B, Josa-Prado F, de Castro F, Arribas M, Bello-Morales* R, and López-Guerrero JA (2024) Herpes Simplex Virus type 1 inhibits autophagy in glial cells but requires ATG5 for the success of viral replication. Front. Microbiol. 15:1411655 (doi: https://doi.org/10.3389/fmicb.2024.1411655 ).
Cajal´s contributions to vestibular research
Espinosa-Sánchez JM, Pérez-Fernández N, de Castro F, and Batuecas-Caletrio A. (2024) Cajal´s contributions to vestibular research. Front. Neuroanat. 18: 1476640 (doi: https://doi.org/10.3389/fnana.2024.1476640 ).
Aptamers as new promising entities for therapeutics: our experience from the neurological diseases
Hernández-Jiménez M, & de Castro F (2025) Aptamers as new promising entities for therapeutics: our experience from the neurological diseases. Neural Reg. Res. 20(12), 3523-3524 (https://doi.org/10.4103/NRR.NRR-D-24-00667).
The importance of Cajal’s and Lorente de Nó’s Neuroscience to the birth of Cybernetics
Espinosa-Sánchez, J.M., Gómez-Marín, A., & de Castro, F. (2025) The importance of Cajal’s and Lorente de Nó’s Neuroscience to the birth of Cybernetics. The Neuroscientist 31(1), 14-30 (https://doi.org/10.1177/10738584231179932 ; preprint published in 2022 at Open Science Framework: https://doi.org/1031219osf.io/cnq4y ).
SHH signaling in oligodendrogenesis, myelination, demyelinating diseases and remyelination
Marchena*# MA, Sánchez-Camacho* C, Muñoz-Sáez E, Macías-Castellano A, & de Castro# F (2025) SHH signaling in oligodendrogenesis, myelination, demyelinating diseases and remyelination. Neural Reg. Res. In Press (NRR-D-25-00005R1). Saldaña, E., de Castro, F., López, D.E., & Malmierca, M.S. (2025) Miguel A. Merchán and the Cajalian influence: Pioneering Auditory Neuroscience in Spain. Hear. Res. 464, 109323 (1-18; https://doi.org/10.1016/j.heares.2025.109323 ).
Alejandro San Martín Satrústegui como pionero de la neurología española
de Castro, F. (2025 Alejandro San Martín Satrústegui como pionero de la neurología española. Neurosci. Hist. 13(1): 19-37.
Alejandro San Martín Satrústegui: a pioneer of Spanish neurology
de Castro, F. (2025 Alejandro San Martín Satrústegui: a pioneer of Spanish neurology. Neurosci. Hist. 13(1): 19-37.