Neuroanatomía funcional de enfermedades raras
LÍNEA DE INVESTIGACIÓN
Empleo de herramientas prosinaptogénicas para contrarrestar la pérdida temprana de sinapsis en modelos animales de la enfermedad de Alzheimer. Caracterización de un modelo celular humano para permitir un seguimiento individualizado de la progresión de la enfermedad en pacientes con Alzheimer.
UBICACIÓN
Instituto de Tecnologías Biomédicas (ITB) Universidad de La Laguna (ULL) Tenerife
Miembros del equipo
INVESTIGADOR PRINCIPAL
- Acebes Vindel, Ángel
MIEMBROS
- Laura García
- Salvador Alarcón
- Paula Cuende
- Davide Borgado
Publicaciones recientes
The Subcortical Default Mode Network and Alzheimer’s Disease: A systematic review and Activation Likelihood Estimation Meta-Analysis
Seoane SL, van den Heuvel M, Acebes A, Janssen N (2024). The Subcortical Default Mode Network and Alzheimer’s Disease: A systematic review and Activation Likelihood Estimation Meta-Analysis. Brain Communications 6(2):fcae128.
Biomarkers in Alzheimer’s Disease: Are Olfactory Neuronal Precursors Useful for Antemortem Biomarker Research?
Santillán-Morales V; Rodriguez-Espinosa N; Muñoz-Estrada J; Alarcón-Elizalde S; Acebes A (AC: Autor de correspondencia); Benítez-King G (AC) (2024) Biomarkers in Alzheimer’s Disease: Are Olfactory Neuronal Precursors Useful for Antemortem Biomarker Research? Brain Sciences 14(1): 46.
Refractive index estimation in biological tissues by quantitative phase imaging
Cairós C (AC); Oliva-García R; Siverio G; Trujillo-Sevilla JM; Rodríguez-Ramos JM; Acebes A (AC) (2023) Refractive index estimation in biological tissues by quantitative phase imaging. Optical Materials 142:114087.
Publicaciones más relevantes
Pridopidine Promotes Synaptogenesis and Reduces Spatial Memory Deficits in the Alzheimer’s Disease APP/PS1 Mouse Model
Estevez-Silva HM; Cuesto G; Romero N; Brito-Armas JM; Acevedo-Arocena A; Acebes A (AC); Marcellino D (AC) (2022) Pridopidine Promotes Synaptogenesis and Reduces Spatial Memory Deficits in the Alzheimer’s Disease APP/PS1 Mouse Model. Neurotherapeutics 19:1566–1587.
Mapping the transcriptomic changes of endothelial compartment in human hippocampus across aging and mild cognitive impairment
Guebel DV; Torres NV; Acebes A (2021) Mapping the transcriptomic changes of endothelial compartment in human hippocampus across aging and mild cognitive impairment. Biology Open 10(5) bio057950.
PI3K activation prevents Aβ42-induced synapse loss and favors insoluble amyloid deposit formation
Arnés M; Romero N; Casas-Tintó S (AC); Acebes A (AC); Ferrús A (AC) (2020) PI3K activation prevents Aβ42-induced synapse loss and favors insoluble amyloid deposit formation. Molecular Biology of the Cell 31(4): 244-260.
PI3K activation controls synaptogenesis and spinogenesis in hippocampal neurons
Cuesto G; Enriquez-Barreto L; Carames C; Acebes A (AC); Morales M (AC) (2011). PI3K activation controls synaptogenesis and spinogenesis in hippocampal neurons. Journal of Neuroscience 31: 2721-2733.
Age-independent synaptogenesis by Phosphoinositide 3 Kinase
Martín-Peña A; Acebes A; Rodríguez JR; Sorribes A; de Polavieja GG; Fernández-Fúnez P; Ferrús A (2006). Age-independent synaptogenesis by Phosphoinositide 3 Kinase. Journal of Neuroscience 26: 10199-10208.