Neurodesarrollo y Organoides Olfativos
LÍNEA DE INVESTIGACIÓN
Investigación de la heterogeneidad y dinámica de los progenitores del epitelio olfativo, combinando trazado de linajes, organoides y microscopía avanzada. Nuestro objetivo es comprender los mecanismos del neurodesarrollo y desarrollar modelos de enfermedades neurológicas, fomentando la colaboración científica internacional y la integración estrecha entre ciencia básica y traslacional.
UBICACIÓN
Instituto de Investigación en Enfermedades Raras (IIER), Instituto de Salud Carlos III (ISCIII), Majadahonda, Madrid
Miembros del equipo
INVESTIGADORA PRINCIPAL
- Figueres Oñate, María
Publicaciones recientes
Genetic Tracing of Progenitors from Embryo to Postnatal Brain. Neural Stem Cells: Methods and Protocols
Ojalvo-Sanz AC, Figueres-Oñate M, Barriola S., and López-Mascaraque L. (2025). Genetic Tracing of Progenitors from Embryo to Postnatal Brain. Neural Stem Cells: Methods and Protocols. Book series: Methods in Molecular Biology. Springer 2025.
StarTrack: Mapping Cellular Fates with Inheritable Color Codes. In Lineage Tracing: Methods and Protocols
Figueres-Oñate M*, Ojalvo-Sanz AC, and López-Mascaraque L. (2025). StarTrack: Mapping Cellular Fates with Inheritable Color Codes. In Lineage Tracing: Methods and Protocols (pp. 311-325). New York, NY: Springer US.
Chapter 26: Olfactory System Embryonic Development. Kaufman’s Atlas of Mouse Development Supplement. 2nd Edition
Figueres-Oñate M, and López-Mascaraque L. (2024). Chapter 26: Olfactory System Embryonic Development. Kaufman’s Atlas of Mouse Development Supplement. 2nd Edition – Dec 10, 2024
Publicaciones más relevantes
Deciphering neural heterogeneity through cell lineage tracing
Figueres-Oñate M, Sánchez-González R, López-Mascaraque L. (2021) Deciphering neural heterogeneity through cell lineage tracing. Cell Mol Life Sci. 2021 Mar;78(5):1971-1982. doi: 10.1007/s00018-020-03689-3.
Lineage Tracing and Cell Potential of Postnatal Single Progenitor Cells In Vivo
Figueres-Oñate M, Sánchez-Villalón M, Sánchez-González R, López-Mascaraque L. (2019). Lineage Tracing and Cell Potential of Postnatal Single Progenitor Cells In Vivo. Stem Cell Reports. 2019 Oct 8;13(4):700-712. doi: 10.1016/j.stemcr.2019.08.010.
Development of Ependymal and Postnatal Neural Stem Cells and Their Origin from a Common Embryonic Progenitor
Redmond SA, Figueres-Oñate M, Obernier K, et al., Alvarez-Buylla A. (2019). Development of Ependymal and Postnatal Neural Stem Cells and Their Origin from a Common Embryonic Progenitor. Cell Rep. 2019 Apr 9;27(2):429-441.e3. doi: 10.1016/j.celrep.2019.01.088.
UbC-StarTrack, a clonal method to target the entire progeny of individual progenitors.
Figueres-Oñate M, García-Marqués J, López-Mascaraque L. (2016). UbC-StarTrack, a clonal method to target the entire progeny of individual progenitors. Scientific Reports. 2016; 6(1). doi: 10.1038/srep33896.
Multiple origins and modularity in the spatiotemporal emergence of cerebellar astrocyte heterogeneity
Cerrato V, Parmigiani E, Figueres-Oñate M, et al., Buffo A. (2018). Multiple origins and modularity in the spatiotemporal emergence of cerebellar astrocyte heterogeneity. PLOS Biology. 2018; 16(9):e2005513. doi: 10.1371/journal.pbio.2005513