Neuroproteómica Clínica
LÍNEA DE INVESTIGACIÓN
Aplicación de metodologías multi-ómicas, biología de sistemas y reposicionamiento de fármacos en patologías de afectación olfativa (Alzheimer, parkinson y rinosinusitis crónica)
UBICACIÓN
Navarrabiomed, centro de investigación biomédica
Miembros del equipo
INVESTIGADOR PRINCIPAL
- Santamaría, Enrique
MIEMBROS
- Mercedes Lachén-Montes
- Paz Cartas-Cejudo
- Elena Anaya-Cubero
- Marina De Miguel
- Leire Extramiana
- Sofía Goya
Publicaciones recientes
Combination of Antibody Arrays to Characterize the Effect of Neuropathological Stimulus in Human Olfactory Neuroepithelial Cells
Lachén-Montes M, Anaya-Cubero E, Cartas-Cejudo P, Extramiana L, Fernández-Irigoyen J, Santamaría E.Combination of Antibody Arrays to Characterize the Effect of Neuropathological Stimulus in Human Olfactory Neuroepithelial Cells. Methods Mol Biol. 2025;2929:227-238. doi: 10.1007/978-1-0716-4595-6_17. PMID: 40601155
Impact of medication use on olfactory performance in older adults. Front Public Health
Izco-Cubero M, Zambom-Ferraresi F, Zambom-Ferraresi F, de la Riva MLFG, Santamaría E, Fernandez-Irigoyen J, Lachén-Montes M, Lasarte JJ, Uzcanga-Lacabe M, Fernandez S, Martin GSS, Maraví-Aznar E, Martinez-Velilla N. Impact of medication use on olfactory performance in older adults. Front Public Health. 2025 Apr 3;13:1554459. doi: 10.3389/fpubh.2025.1554459. eCollection 2025. PMID: 40247865
Unraveling Potential Tauopathy Biomarkers in Cerebrospinal Fluid: Insights from Olfactory Tract Data
Lachén-Montes M, Cartas-Cejudo P, Anaya-Cubero E, Cortés A, Fernández-Irigoyen J, Santamaría E. Unraveling Potential Tauopathy Biomarkers in Cerebrospinal Fluid: Insights from Olfactory Tract Data.
Methods Mol Biol. 2025;2914:261-273. doi: 10.1007/978-1-0716-4462-1_19. PMID: 40167924
Proteomic interrogation of the human olfactory system: the road ahead
Anaya-Cubero E, Cartas-Cejudo P, De Miguel M, Extramiana L, Romero-Murillo S, Lachén-Montes M, Fernández-Irigoyen J, Santamaría E. Proteomic interrogation of the human olfactory system: the road ahead.
Expert Rev Proteomics. 2025 Mar;22(3):85-88. doi: 10.1080/14789450.2025.2476966. Epub 2025 Mar 11. PMID: 40047107
Data-driven drug repositioning using olfactory omics profiles: challenges and perspectives in neurodegeneration
Cartas-Cejudo P, Cortés A, Lachén-Montes M, Anaya-Cubero E, Fernández-Irigoyen J, Santamaría E. Data-driven drug repositioning using olfactory omics profiles: challenges and perspectives in neurodegeneration.
Neural Regen Res. 2025 Jul 1;20(7):1997-1998. doi: 10.4103/NRR.NRR-D-24-00334. Epub 2024 Jul 10. PMID: 39254556
Involvement of Glucosamine 6 Phosphate Isomerase 2 (GNPDA2) Overproduction in β-Amyloid- and Tau P301L-Driven Pathomechanisms
Lachén-Montes M, Cartas-Cejudo P, Cortés A, Anaya-Cubero E, Peral E, Ausín K, Díaz-Peña R, Fernández-Irigoyen J, Santamaría E.Involvement of Glucosamine 6 Phosphate Isomerase 2 (GNPDA2) Overproduction in β-Amyloid- and Tau P301L-Driven Pathomechanisms. Biomolecules. 2024 Mar 25;14(4):394. doi: 10.3390/biom14040394. PMID: 38672412
Neuropathological stage-dependent proteome mapping of the olfactory tract in Alzheimer's disease: From early olfactory-related omics signatures to computational repurposing of drug candidates
Cartas-Cejudo P, Cortés A, Lachén-Montes M, Anaya-Cubero E, Puerta E, Solas M, Fernández-Irigoyen J, Santamaría E.Neuropathological stage-dependent proteome mapping of the olfactory tract in Alzheimer’s disease: From early olfactory-related omics signatures to computational repurposing of drug candidates. Brain Pathol. 2024 Jul;34(4):e13252. doi: 10.1111/bpa.13252. Epub 2024 Mar 7. PMID: 38454090
Mapping the human brain proteome: opportunities, challenges, and clinical potential
Cartas-Cejudo P, Cortés A, Lachén-Montes M, Anaya-Cubero E, Peral E, Ausín K, Díaz-Peña R, Fernández-Irigoyen J, Santamaría E. Mapping the human brain proteome: opportunities, challenges, and clinical potential.
Expert Rev Proteomics. 2024 Jan-Mar;21(1-3):55-63. doi: 10.1080/14789450.2024.2313073. Epub 2024 Feb 5. PMID: 38299555
Improvement of cognitive function in wild-type and Alzheimer´s disease mouse models by the immunomodulatory properties of menthol inhalation or by depletion of T regulatory cells
Casares N, Alfaro M, Cuadrado-Tejedor M, Lasarte-Cia A, Navarro F, Vivas I, Espelosin M, Cartas-Cejudo P, Fernández-Irigoyen J, Santamaría E, García-Osta A, Lasarte JJ. Improvement of cognitive function in wild-type and Alzheimer´s disease mouse models by the immunomodulatory properties of menthol inhalation or by depletion of T regulatory cells. Front Immunol. 2023 Apr 27;14:1130044. doi: 10.3389/fimmu.2023.1130044. eCollection 2023. PMID: 37187754
Sex-divergent effects on the NAD+-dependent deacetylase sirtuin signaling across the olfactory-entorhinal-amygdaloid axis in Alzheimer's and Parkinson's diseases
Cartas-Cejudo P, Lachén-Montes M, Ferrer I, Fernández-Irigoyen J, Santamaría E.Sex-divergent effects on the NAD+-dependent deacetylase sirtuin signaling across the olfactory-entorhinal-amygdaloid axis in Alzheimer’s and Parkinson’s diseases. Biol Sex Differ. 2023 Feb 8;14(1):5. doi: 10.1186/s13293-023-00487-x. PMID: 36755296
Deep Phosphoproteome Landscape of Interhemispheric Functionality of Neuroanatomical Regions of the Human Brain
Deep Phosphoproteome Landscape of Interhemispheric Functionality of Neuroanatomical Regions of the Human Brain. Biswas D, Kumari N, Lachén-Montes M, Dutta S, Agrawal I, Samanta D, Shenoy SV, Halder A, Fernández-Irigoyen J, Padhye AR, Srivastava S, Santamaría E. Deep Phosphoproteome Landscape of Interhemispheric Functionality of Neuroanatomical Regions of the Human Brain. J Proteome Res. 2023 Apr 7;22(4):1043-1055. doi: 10.1021/acs.jproteome.2c00244. Epub 2022 Nov 1. PMID: 36317652