Plasticidad neuronal y neurorreparación
LÍNEA DE INVESTIGACIÓN
Análisis de los fenómenos relacionados con la muerte neuronal, con el objetivo de ralentizar o evitar la neurodegeneración o estimular la regeneración, enfocados en el sistema olfativo y el cerebelo. Investigación de indicadores tempranos de neurodegeneración, procesos de inflamación, alteraciones secundarias, temporalización, etc. Terapia celular, terapia farmacológica o génica.
UBICACIÓN
Instituto de Neurociencias de Castilla y León, Universidad de Salamanca
Miembros del equipo
INVESTIGADOR PRINCIPAL
- Weruaga Prieto, Eduardo
MIEMBROS
- José R. Alonso Peña
- Jesús M.ª García Briñón
- Carmelo A. Ávila Zarza
- David Díaz López
- Jorge Valero Gómez-Lobo
- David Pérez Boyero
- Eva Mª Baranda Alonso
- Valeria Lorena Cabedo Navarro
- Pablo González Téllez de Meneses
- Teresa Cocho Curto
- Sara Sánchez Monreal
- Yoan Reynaldo Torres Cruz
- Carla Escudero Solano
Publicaciones recientes
A bottom-up approach identifies the antipsychotic and antineoplastic trifluoperazine and the ribose derivative deoxytubercidin as novel microglial phagocytosis inhibitors
A bottom-up approach identifies the antipsychotic and antineoplastic trifluoperazine and the ribose derivative deoxytubercidin as novel microglial phagocytosis inhibitors. GLIA, Vol. 73, Núm. 2, pp. 330-351
Age and Hypertension Synergize With Dehydration to Cause Renal Frailty in Rats and Predispose Them to Intrinsic Acute Kidney Injury
Age and Hypertension Synergize With Dehydration to Cause Renal Frailty in Rats and Predispose Them to Intrinsic Acute Kidney Injury. Laboratory Investigation, Vol. 105, Núm. 3
Neuroprotective Effects of VEGF-B in a Murine Model of Aggressive Neuronal Loss with Childhood Onset. International Journal of Molecular Sciences
Neuroprotective Effects of VEGF-B in a Murine Model of Aggressive Neuronal Loss with Childhood Onset. International Journal of Molecular Sciences, Vol. 26, Núm. 2
Age-dependent energy metabolism and transcriptome changes in urine-derived stem cells
Age-dependent energy metabolism and transcriptome changes in urine-derived stem cells. Mechanisms of Ageing and Development, Vol. 218
Enhanced mitochondrial fusion during a critical period of synaptic plasticity in adult-born neurons
Enhanced mitochondrial fusion during a critical period of synaptic plasticity in adult-born neurons. Neuron, Vol. 112, Núm. 12, pp. 1997-2014.e6
Intracerebellar injection of monocytic immature myeloid cells prevents the adverse effects caused by stereotactic surgery in a model of cerebellar neurodegeneration
Intracerebellar injection of monocytic immature myeloid cells prevents the adverse effects caused by stereotactic surgery in a model of cerebellar neurodegeneration. Journal of Neuroinflammation, Vol. 21, Núm. 1
Volumestj: A new method and tool for volumetric estimation of brain structures after serial sectioning
Volumestj: A new method and tool for volumetric estimation of brain structures after serial sectioning. Neuromethods (Humana Press Inc.), pp. 129-176
Dual role of Apolipoprotein D as long-term instructive factor and acute signal conditioning microglial secretory and phagocytic responses
Dual role of Apolipoprotein D as long-term instructive factor and acute signal conditioning microglial secretory and phagocytic responses. Frontiers in Cellular Neuroscience, Vol. 17
Immunohistochemical distribution of secretagogin in the mouse brain
Immunohistochemical distribution of secretagogin in the mouse brain. Frontiers in Neuroanatomy, Vol. 17
Insulin-degrading enzyme (IDE) as a modulator of microglial phenotypes in the context of Alzheimer’s disease and brain aging
Insulin-degrading enzyme (IDE) as a modulator of microglial phenotypes in the context of Alzheimer’s disease and brain aging. Journal of Neuroinflammation, Vol. 20, Núm. 1
Lobe X of the Cerebellum: A Natural Neuro-Resistant Region
Lobe X of the Cerebellum: A Natural Neuro-Resistant Region. Anatomia, Vol. 2, Núm. 1, pp. 43-62
Microglial phagocytosis dysfunction in stroke is driven by energy depletion and induction of autophagy
Microglial phagocytosis dysfunction in stroke is driven by energy depletion and induction of autophagy. Autophagy, Vol. 19, Núm. 7, pp. 1952-1981
Oleoylethanolamide Treatment Modulates Both Neuroinflammation and Microgliosis, and Prevents Massive Leukocyte Infiltration to the Cerebellum in a Mouse Model of Neuronal Degeneration
Oleoylethanolamide Treatment Modulates Both Neuroinflammation and Microgliosis, and Prevents Massive Leukocyte Infiltration to the Cerebellum in a Mouse Model of Neuronal Degeneration. International Journal of Molecular Sciences, Vol. 24, Núm. 11
Recent Advances in Extracellular Vesicles in Amyotrophic Lateral Sclerosis and Emergent Perspectives
Recent Advances in Extracellular Vesicles in Amyotrophic Lateral Sclerosis and Emergent Perspectives. Cells, Vol. 12, Núm. 13
Stereotactic Radiosurgery and Highly Active Antiretroviral Therapy for HIV-Related Primary Central Nervous System Lymphomas: A Prospective Study Analyzing the Efficacy and Safety
Stereotactic Radiosurgery and Highly Active Antiretroviral Therapy for HIV-Related Primary Central Nervous System Lymphomas: A Prospective Study Analyzing the Efficacy and Safety. Neurosurgery Practice, Vol. 5, Núm. 1
The eNOS isoform exhibits increased expression and activation in the main olfactory bulb of nNOS knock-out mice
The eNOS isoform exhibits increased expression and activation in the main olfactory bulb of nNOS knock-out mice. Frontiers in Cellular Neuroscience, Vol. 17
Urine-derived stem cells in neurological diseases: current state-of-the-art and future directions
Urine-derived stem cells in neurological diseases: current state-of-the-art and future directions. Frontiers in Molecular Neuroscience, Vol. 16
Specific Glutamylation Patterns of the Cytoskeleton Confer Neuroresistance to Lobe X of the Cerebellum in a Model of Childhood-Onset Neurodegeneration with Cerebellar Atrophy
Hernández-Pérez, C., Calderón-García, A. A., Pérez-Boyero, D., González-Núñez, V., Weruaga, E., & Díaz, D. (2025). Specific Glutamylation Patterns of the Cytoskeleton Confer Neuroresistance to Lobe X of the Cerebellum in a Model of Childhood-Onset Neurodegeneration with Cerebellar Atrophy. International Journal of Molecular Sciences, 26(21), 10378. https://doi.org/10.3390/ijms262110378